An anti-Siglec-8 Antibody Depletes Sputum Eosinophils from Asthmatic Subjects and Inhibits Lung Mast Cells

BACKGROUND: Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is expressed on mast cells and eosinophils, but information about Siglec-8 expression and function in the lung is limited. A humanized antibody, AK002, targeting Siglec-8 is undergoing development for treatment of diseases associa...

Full description

Saved in:
Bibliographic Details
Published in:Clin Exp Allergy
Main Authors: Kerr, Sheena C., Gonzalez, Jeanmarie R., Schanin, Julia, Peters, Michael C., Lambrecht, Bart N., Brock, Emily C., Charbit, Annabelle, Ansel, K. Mark, Youngblood, Bradford A., Fahy, John V.
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610812/
https://ncbi.nlm.nih.gov/pubmed/32542913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.13681
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items