Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection

The interplay between host and pathogen relies heavily on rapid protein synthesis and accurate protein targeting to ensure pathogen destruction. To gain insight into this dynamic interface, we combined click-chemistry with pulsed stable isotope labeling of amino acids in cell culture (pSILAC-AHA) to...

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Publicado no:Nat Microbiol
Main Authors: Selkrig, Joel, Li, Nan, Hausmann, Annika, Mangan, Matthew S. J., Zietek, Matylda, Mateus, André, Bobonis, Jacob, Sueki, Anna, Imamura, Haruna, El Debs, Bachir, Sigismondo, Gianluca, Florea, Bogdan I., Overkleeft, Herman S., Kopitar-Jerala, Natasa, Turk, Boris, Beltrao, Pedro, Savitski, Mikhail, Latz, Eicke, Hardt, Wolf-Dietrich, Krijgsveld, Jeroen, Typas, Athanasios
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610801/
https://ncbi.nlm.nih.gov/pubmed/32514074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0736-7
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