Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling

Direct targeting of the downstream MAPK pathway to suppress ERK activation in KRAS and BRAF mutant colorectal cancer (CRC) has proven clinically unsuccessful, but promising results have been obtained with combination therapies including EGFR-inhibition. To elucidate the interplay between EGF signali...

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Published in:Nat Cell Biol
Main Authors: Ponsioen, Bas, Post, Jasmin B., des Amorie, Julian R. Buissant, Laskaris, Dimitrios, van Ineveld, Ravian L., Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F., Vries, Rob G.J., Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B., Trusolino, Livio, Bos, Johannes L., Snippert, Hugo J.G.
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610573/
https://ncbi.nlm.nih.gov/pubmed/33795873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-021-00654-5
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