Regulation of single-cell genome organization into TADs and chromatin nanodomains

The genome folds into a hierarchy of three-dimensional (3D) structures within the nucleus. At the sub-megabase scale, chromosomes form topologically associating domains (TADs)(1–4). However, how TADs fold in single cells remains elusive. Here, we revealed TAD features inaccessible to cell-population...

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Bibliografiset tiedot
Julkaisussa:Nat Genet
Päätekijät: Szabo, Quentin, Donjon, Axelle, Jerković, Ivana, Papadopoulos, Giorgio L., Cheutin, Thierry, Bonev, Boyan, Nora, Elphège P., Bruneau, Benoit G., Bantignies, Frédéric, Cavalli, Giacomo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610512/
https://ncbi.nlm.nih.gov/pubmed/33077913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00716-8
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