Evolutionary dynamics of neoantigens in growing tumors

Cancers accumulate mutations that lead to neoantigens, novel peptides that elicit an immune response, and consequently undergo evolutionary selection. Here we establish how negative selection shapes the clonality of neoantigens in a growing cancer, by constructing a mathematical model of neoantigen...

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Publicado no:Nat Genet
Main Authors: Lakatos, Eszter, Williams, Marc J., Schenck, Ryan O., Cross, William C. H., Househam, Jacob, Zapata, Luis, Werner, Benjamin, Gatenbee, Chandler, Robertson-Tessi, Mark, Barnes, Chris P., Anderson, Alexander R. A., Sottoriva, Andrea, Graham, Trevor A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610467/
https://ncbi.nlm.nih.gov/pubmed/32929288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0687-1
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