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Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in somatic cells. However the link, in somatic evolution, between dN/dS values and fi...
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| Publicado no: | eLife |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7105384/ https://ncbi.nlm.nih.gov/pubmed/32223898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48714 |
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