Ultra-Low DNA Input into Whole Genome Methylation Assays and Detection of Oncogenic Methylation and Copy Number Variants in Circulating Tumour DNA

Background: Abnormal CpG methylation in cancer is ubiquitous and generally detected in tumour specimens using a variety of techniques at a resolution encompassing single CpG loci to genome wide coverage. Analysis of samples with very low DNA inputs, such as formalin fixed (FFPE) biopsy specimens fro...

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Publicat a:Epigenomes
Autors principals: Whalley, Celina, Payne, Karl, Domingo, Enric, Blake, Andrew, Richman, Susan, Brooks, Jill, Batis, Nikolaos, Spruce, Rachel, Mehanna, Hisham, Nankivell, Paul, Beggs, Andrew D.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610445/
https://ncbi.nlm.nih.gov/pubmed/33777442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/epigenomes5010006
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