PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Mutant KRAS modulates the metabolic plasticity of cancer cells conferring growth advantage during hypoxia, but the molecular underpinnings are largely unknown. Using a lipidomic screen, we found that PLCγ1 is suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines. Suppr...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Saliakoura, Maria, Sebastiano, Matteo Rossi, Pozzato, Chiara, Heidel, Florian H., Schnöder, Tina M., Prince, Spasenija Savic, Bubendorf, Lukas, Pinton, Paolo, Schmid, Ralph, Baumgartner, Johanna, Freigang, Stefan, Berezowska, Sabina A., Rimessi, Alessandro, Konstantinidou, Georgia
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610419/
https://ncbi.nlm.nih.gov/pubmed/33077911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00592-8
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