PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Mutant KRAS modulates the metabolic plasticity of cancer cells conferring growth advantage during hypoxia, but the molecular underpinnings are largely unknown. Using a lipidomic screen, we found that PLCγ1 is suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines. Suppr...

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Detaylı Bibliyografya
Yayımlandı:Nat Cell Biol
Asıl Yazarlar: Saliakoura, Maria, Sebastiano, Matteo Rossi, Pozzato, Chiara, Heidel, Florian H., Schnöder, Tina M., Prince, Spasenija Savic, Bubendorf, Lukas, Pinton, Paolo, Schmid, Ralph, Baumgartner, Johanna, Freigang, Stefan, Berezowska, Sabina A., Rimessi, Alessandro, Konstantinidou, Georgia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610419/
https://ncbi.nlm.nih.gov/pubmed/33077911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00592-8
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