PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Mutant KRAS modulates the metabolic plasticity of cancer cells conferring growth advantage during hypoxia, but the molecular underpinnings are largely unknown. Using a lipidomic screen, we found that PLCγ1 is suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines. Suppr...

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Publicat a:Nat Cell Biol
Autors principals: Saliakoura, Maria, Sebastiano, Matteo Rossi, Pozzato, Chiara, Heidel, Florian H., Schnöder, Tina M., Prince, Spasenija Savic, Bubendorf, Lukas, Pinton, Paolo, Schmid, Ralph, Baumgartner, Johanna, Freigang, Stefan, Berezowska, Sabina A., Rimessi, Alessandro, Konstantinidou, Georgia
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610419/
https://ncbi.nlm.nih.gov/pubmed/33077911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00592-8
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