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Senescence as a therapeutically relevant response to CDK4/6 inhibitors
Cyclin-dependent kinases 4 and 6 (CDK4/6) phosphorylate and inhibit retinoblastoma (RB) family proteins. Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional program that initiates S phase. Due to the critical role that this pathway has in regulating cell cycle pro...
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| 出版年: | Oncogene |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610384/ https://ncbi.nlm.nih.gov/pubmed/32541838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1354-9 |
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