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Senescence as a therapeutically relevant response to CDK4/6 inhibitors
Cyclin-dependent kinases 4 and 6 (CDK4/6) phosphorylate and inhibit retinoblastoma (RB) family proteins. Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional program that initiates S phase. Due to the critical role that this pathway has in regulating cell cycle pro...
Guardat en:
| Publicat a: | Oncogene |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610384/ https://ncbi.nlm.nih.gov/pubmed/32541838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1354-9 |
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