STEEP mediates STING ER exit and activation of signaling

STING is essential for control of infections and for tumor immunosurveillance, but can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER), and traffics following stimulation to ERGIC/Golgi where signaling occurs. Although STING ER exit is the rate-limiting step in...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Zhang, Bao-cun, Nandakumar, Ramya, Reinert, Line S, Huang, Jinrong, Laustsen, Anders, Gao, Zong-liang, Sun, Cheng-long, Jensen, Søren Beck, Troldborg, Anne, Assil, Sonia, Berthelsen, Martin F., Scavenius, Carsten, Zhang, Yan, Windross, Samuel J, Olagnier, David, Prabakaran, Thaneas, Bodda, Chiranjeevi, Narita, Ryo, Cai, Yujia, Zhang, Cong-gang, Stenmark, Harald, Doucet, Christine M, Noda, Takeshi, Guo, Zheng, Goldbach-Mansky, Raphaela, Hartmann, Rune, Chen, Zhijian J, Enghild, Jan J, Bak, Rasmus O, Thomsen, Martin K., Paludan, Søren R
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610351/
https://ncbi.nlm.nih.gov/pubmed/32690950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0730-5
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