Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance

Multiple drug resistance (MDR) is a tough problem in developing hepatocellular carcinoma (HCC) therapy. Here, we developed TPGS-coated cationic liposomes with Bcl-2 siRNA corona to load doxorubicin (Dox) i.e., Bcl-2 siRNA/Dox-TPGS-LPs, to enhance anticancer effect of Dox in HCC-MDR. TPGS i.e., d-α-t...

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Publicat a:Asian J Pharm Sci
Autors principals: Li, Yinghuan, Tan, Xi, Liu, Xuhan, Liu, Lingyan, Fang, Yan, Rao, Rong, Ren, Yuanyuan, Yang, Xiangliang, Liu, Wei
Format: Artigo
Idioma:Inglês
Publicat: Shenyang Pharmaceutical University 2020
Matèries:
Original Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610212/
https://ncbi.nlm.nih.gov/pubmed/33193866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2019.10.003
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