Inhibition of cell proliferation through an ATP-responsive co-delivery system of doxorubicin and Bcl-2 siRNA

Herein, DNA duplex was constructed through the hybridization of adenosine triphosphate (ATP)-responsive aptamer and its cDNA in which GC-rich motif could be used to load doxorubicin (DOX), and then, cationic polymer PEI25K was used as a carrier to simultaneously condense DOX-Duplex and Bcl-2 siRNA t...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Zhang, Jianxu, Wang, Yudi, Chen, Jiawen, Liang, Xiao, Han, Haobo, Yang, Yan, Li, Quanshun, Wang, Yanbo
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503501/
https://ncbi.nlm.nih.gov/pubmed/28740380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S135086
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