Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster

Hyperphosphorylated Tau protein is the main component of the neurofibrillary tangles, characterizing degenerating neurons in Alzheimer’s disease and other Tauopathies. Expression of human Tau protein in Drosophila CNS results in increased toxicity, premature mortality and learning and memory deficit...

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Publicado en:Front Mol Neurosci
Autores principales: Keramidis, Iason, Vourkou, Ergina, Papanikolopoulou, Katerina, Skoulakis, Efthimios M. C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609872/
https://ncbi.nlm.nih.gov/pubmed/33192295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.569520
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