Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes

Telomeres are DNA-protein structures at the ends of chromosomes essential in maintaining chromosomal stability. Observational studies have identified associations between telomeres and elevated cancer risk, including hematologic malignancies; but biologic mechanisms relating telomere length to cance...

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Pubblicato in:PLoS Genet
Autori principali: Brown, Derek W., Lin, Shu-Hong, Loh, Po-Ru, Chanock, Stephen J., Savage, Sharon A., Machiela, Mitchell J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608979/
https://ncbi.nlm.nih.gov/pubmed/33090998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009078
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