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Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway

Oxidative stress caused by chronic intermittent hypoxia (CIH) is the hallmark of obstructive sleep apnea (OSA). Among the first line of defense against oxidative stress is the dismutation of superoxide radicals, which in the mitochondria is carried out by manganese superoxide dismutase (SOD2). In th...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Song, Jie-qiong, Jiang, Li-yan, Fu, Cui-ping, Wu, Xu, Liu, Zi-long, Xie, Liang, Wu, Xiao-dan, Hao, Sheng-yu, Li, Shan-qun
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608479/
https://ncbi.nlm.nih.gov/pubmed/32066884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0349-y
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