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T-cell expression of Bruton’s tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia

The role of Bruton’s tyrosine kinase (BTK) in BCR signaling is well defined, and BTK is involved in B-cell development, differentiation, and malignancies. However, the expression of Btk in T cells and its role in T-cell function remain largely unknown. Here, we unexpectedly found high expression and...

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Bibliografski detalji
Izdano u:Cell Mol Immunol
Glavni autori: Xia, Simo, Liu, Xiang, Cao, Xuetao, Xu, Sheng
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608443/
https://ncbi.nlm.nih.gov/pubmed/31431692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0270-9
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