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Lineage tracing on transcriptional landscapes links state to fate during differentiation
A challenge in biology is to associate molecular differences among progenitor cells with their capacity to generate mature cell types. Here, we use expressed DNA barcodes to clonally trace transcriptomes over time, applied to study fate determination in hematopoiesis. We identify states of primed fa...
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| Udgivet i: | Science |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7608074/ https://ncbi.nlm.nih.gov/pubmed/31974159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw3381 |
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