IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans

BACKGROUND & AIMS: Unregulated activity of interleukin (IL) 22 promotes intestinal tumorigenesis in mice. IL22 binds the antagonist IL22 subunit alpha 2 (IL22RA2, also called IL22BP). We studied whether alterations in IL22BP contribute to colorectal carcinogenesis in humans and mice. METHODS: We...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Gastroenterology
Main Authors: Kempski, Jan, Giannou, Anastasios D., Riecken, Kristoffer, Zhao, Lilan, Steglich, Babett, Lücke, Jöran, Garcia-Perez, Laura, Karstens, Karl-Frederick, Wöstemeier, Anna, Nawrocki, Mikolaj, Pelczar, Penelope, Witkowski, Mario, Nilsson, Sven, Konczalla, Leonie, Shiri, Ahmad Mustafa, Kempska, Joanna, Wahib, Ramez, Brockmann, Leonie, Huber, Philipp, Gnirck, Ann-Christin, Turner, Jan-Eric, Zazara, Dimitra E., Arck, Petra C., Stein, Alexander, Simon, Ronald, Daubmann, Anne, Meiners, Jan, Perez, Daniel, Strowig, Till, Koni, Pandelakis, Kruglov, Andrey A., Sauter, Guido, Izbicki, Jakob R., Guse, Andreas H., Rösch, Thomas, Lohse, Ansgar W., Flavell, Richard A., Gagliani, Nicola, Huber, Samuel
פורמט: Artigo
שפה:Inglês
יצא לאור: W.B. Saunders 2020
נושאים:
Original Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607422/
https://ncbi.nlm.nih.gov/pubmed/32585307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.06.033
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