TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Perez, Laura Garcia, Kempski, Jan, M. McGee, Heather, Pelzcar, Penelope, Agalioti, Theodora, Giannou, Anastasios, Konczalla, Leonie, Brockmann, Leonie, Wahib, Ramez, Xu, Hao, Vesely, Maria Carolina Amezcua, Soukou, Shiwa, Steglich, Babett, Bedke, Tanja, Manthey, Carolin, Seiz, Oliver, Diercks, Björn-Philipp, Gnafakis, Stylianos, Guse, Andreas H., Perez, Daniel, Izbicki, Jakob R., Gagliani, Nicola, Flavell, Richard A., Huber, Samuel
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248087/
https://ncbi.nlm.nih.gov/pubmed/32451418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16363-w
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