Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in NUDT15 R139C

Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients who are NUDT15 poor metabolizers and consider...

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Detalhes bibliográficos
Publicado no:Yeungnam Univ J Med
Main Authors: Bae, Jaewoan, Choe, Byung-Ho, Kang, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: Yeungnam University College of Medicine 2020
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606952/
https://ncbi.nlm.nih.gov/pubmed/32438538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12701/yujm.2020.00178
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