Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition

The antimalarial agents artemisinins inhibit cytomegalovirus (CMV) in vitro and in vivo, but their target(s) has been elusive. Using a biotin-labeled artemisinin, we identified the intermediate filament protein vimentin as an artemisinin target, validated by detailed biochemical and biological assay...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Roy, Sujayita, Kapoor, Arun, Zhu, Fei, Mukhopadhyay, Rupkatha, Ghosh, Ayan Kumar, Lee, Hyun, Mazzone, Jennifer, Posner, Gary H., Arav-Boger, Ravit
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606667/
https://ncbi.nlm.nih.gov/pubmed/32855235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014116
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