Inhibition of Human Cytomegalovirus Replication by Artemisinins: Effects Mediated through Cell Cycle Modulation

Artemisinin-derived monomers and dimers inhibit human cytomegalovirus (CMV) replication in human foreskin fibroblasts (HFFs). The monomer artesunate (AS) inhibits CMV at micromolar concentrations, while dimers inhibit CMV replication at nanomolar concentrations, without increased toxicity in HFFs. W...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Roy, Sujayita, He, Ran, Kapoor, Arun, Forman, Michael, Mazzone, Jennifer R., Posner, Gary H., Arav-Boger, Ravit
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468661/
https://ncbi.nlm.nih.gov/pubmed/25870074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00262-15
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