Inhibition of Human Cytomegalovirus Replication by Artemisinins: Effects Mediated through Cell Cycle Modulation

Artemisinin-derived monomers and dimers inhibit human cytomegalovirus (CMV) replication in human foreskin fibroblasts (HFFs). The monomer artesunate (AS) inhibits CMV at micromolar concentrations, while dimers inhibit CMV replication at nanomolar concentrations, without increased toxicity in HFFs. W...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Roy, Sujayita, He, Ran, Kapoor, Arun, Forman, Michael, Mazzone, Jennifer R., Posner, Gary H., Arav-Boger, Ravit
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Antiviral Agents
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468661/
https://ncbi.nlm.nih.gov/pubmed/25870074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00262-15
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