Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome is an ultra-rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. Its pathogenesis is driven most frequently by dysregulated cell-surface control of the alternative pathway of complement secondary to inherited an...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Zhang, Yuzhou, Kremsdorf, Robin, Sperati, C. John, Henriksen, Kammi J, Mori, Mari, Goodfellow, Renee X, Pitcher, Gabriella R, Benson, Cindy, Borsa, Nicolo Ghiringhelli, Taylor, Ronald P, Nester, Carla M, Smith, Richard JH
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606633/
https://ncbi.nlm.nih.gov/pubmed/32540405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2020.05.028
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