Genetic Analysis of 400 Patients Refines Understanding and Implicates a New Gene in Atypical Hemolytic Uremic Syndrome

BACKGROUND: Genetic variation in complement genes is a predisposing factor for atypical hemolytic uremic syndrome (aHUS), a life-threatening thrombotic microangiopathy, however interpreting the effects of genetic variants is challenging and often ambiguous. METHODS: We analyzed 93 complement and coa...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Bu, Fengxiao, Zhang, Yuzhou, Wang, Kai, Borsa, Nicolo Ghiringhelli, Jones, Michael B., Taylor, Amanda O., Takanami, Erika, Meyer, Nicole C., Frees, Kathy, Thomas, Christie P., Nester, Carla, Smith, Richard J.H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287871/
https://ncbi.nlm.nih.gov/pubmed/30377230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070759
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