Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding

High-fat feeding (HFF) leads to gut dysbiosis through unclear mechanisms. We hypothesize that bile acids secreted in response to high-fat diets (HFDs) may act on intestinal Paneth cells, leading to gut dysbiosis. We found that HFF resulted in widespread taxonomic shifts in the bacteria of the ileal...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Zhou, Hui, Zhou, Shi-Yi, Gillilland, Merritt, Li, Ji-Yao, Lee, Allen, Gao, Jun, Zhang, Guanpo, Xu, Xianjun, Owyang, Chung
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605541/
https://ncbi.nlm.nih.gov/pubmed/33055426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138881
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