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Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding
High-fat feeding (HFF) leads to gut dysbiosis through unclear mechanisms. We hypothesize that bile acids secreted in response to high-fat diets (HFDs) may act on intestinal Paneth cells, leading to gut dysbiosis. We found that HFF resulted in widespread taxonomic shifts in the bacteria of the ileal...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7605541/ https://ncbi.nlm.nih.gov/pubmed/33055426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138881 |
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