Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling

Focal adhesion kinase (FAK) is an important mediator of extracellular matrix–integrin mechano-signal transduction that regulates cell motility, survival, and proliferation. As such, FAK is being investigated as a potential therapeutic target for malignant and fibrotic diseases, and numerous clinical...

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Vydáno v:JCI Insight
Hlavní autoři: Weng, Yun, Lieberthal, Tyler J., Zhou, Vivian X., Lopez-Ichikawa, Maya, Armas-Phan, Manuel, Bond, Tristan K., Yoshida, Miya C., Choi, Won-Tak, Chang, Tammy T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605528/
https://ncbi.nlm.nih.gov/pubmed/32910808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141217
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