Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort

PURPOSE: We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic risk score (PRS) based on 313 breast cancer (BC)–associated variants (PRS(313)) and o...

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Udgivet i:Genet Med
Main Authors: Lakeman, Inge M. M., Rodríguez-Girondo, Mar, Lee, Andrew, Ruiter, Rikje, Stricker, Bruno H., Wijnant, Sara R. A., Kavousi, Maryam, Antoniou, Antonis C., Schmidt, Marjanka K., Uitterlinden, André G., van Rooij, Jeroen, Devilee, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605432/
https://ncbi.nlm.nih.gov/pubmed/32624571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-020-0884-4
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