Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity

Human genetic studies recently identified an association of SNPs in the 17-β hydroxysteroid dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease development. Mutant HSD17B13 variants devoid of enzymatic function have been demonstrated to be protective from cirrhosis a...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Ma, Yanling, Karki, Suman, Brown, Philip M., Lin, Dennis D., Podszun, Maren C., Zhou, Wenchang, Belyaeva, Olga V., Kedishvili, Natalia Y., Rotman, Yaron
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604732/
https://ncbi.nlm.nih.gov/pubmed/32973038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000907
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