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Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant
Lemborexant is a dual orexin receptor antagonist approved for treating insomnia. As the solubility of lemborexant is pH‐sensitive, the impact of the gastric acid‐reducing agent (ARA), famotidine, on lemborexant pharmacokinetics was evaluated in a Phase 1 study. Additionally, post hoc analysis of dat...
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| Pubblicato in: | Pharmacol Res Perspect |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7604696/ https://ncbi.nlm.nih.gov/pubmed/33135390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.678 |
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