TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory response; controlled responses confer immunity but uncontrolled responses cause harm. Here we define how a multimodular scaffold, GIV (a.k.a. Girdin), titrates such inflammatory response in macrophages. Upon challenge with e...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Swanson, Lee, Katkar, Gajanan D., Tam, Julian, Pranadinata, Rama F., Chareddy, Yogitha, Coates, Jane, Anandachar, Mahitha Shree, Castillo, Vanessa, Olson, Joshua, Nizet, Victor, Kufareva, Irina, Das, Soumita, Ghosh, Pradipta
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604444/
https://ncbi.nlm.nih.gov/pubmed/33055214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011667117
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