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Vimentin filaments drive migratory persistence in polyploidal cancer cells

Polyploidal giant cancer cells (PGCCs) are multinucleated chemoresistant cancer cells found in heterogeneous solid tumors. Due in part to their apparent dormancy, the effect of PGCCs on cancer progression has remained largely unstudied. Recent studies have highlighted the critical role of PGCCs as a...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Xuan, Botai, Ghosh, Deepraj, Jiang, Joy, Shao, Rachelle, Dawson, Michelle R.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604438/
https://ncbi.nlm.nih.gov/pubmed/33046658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011912117
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