K-Ras–Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated

K-RAS is frequently mutated in human lung adenocarcinomas (ADCs), and the p53 pathway plays a central role in cellular defense against oncogenic K-RAS mutation. However, in mouse lung cancer models, oncogenic K-Ras mutation alone can induce ADCs without p53 mutation, and loss of p53 does not have a...

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Pubblicato in:Mol Cells
Autori principali: Lee, You-Soub, Lee, Ja-Yeol, Song, Soo-Hyun, Kim, Da-Mi, Lee, Jung-Won, Chi, Xin-Zi, Ito, Yoshiaki, Bae, Suk-Chul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Society for Molecular and Cellular Biology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604022/
https://ncbi.nlm.nih.gov/pubmed/33115981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2020.0182
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