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Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing
Chimeric antigen receptor-modified T cells (CAR-T cells) have shown good effects in the treatment of hematologic cancers; however, they may cause on-target off-tumor toxicity because of minimal expression of tumor-associated antigens (TAAs) on normal tissues, particularly in the context of treating...
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| Veröffentlicht in: | Biomark Res |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7602323/ https://ncbi.nlm.nih.gov/pubmed/33292642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-020-00238-9 |
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