Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

Background Hypoxia is a striking feature of most solid tumors and could be used to discriminate tumors from normoxic tissues. Therefore, the design of hypoxia-conditioned Chimeric Antigen Receptor (CAR) T cells is a promising strategy to reduce on-target off-tumor toxicity in adoptive cell therapy....

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Xiaoyan Zhang, Huan He, Chen Zhao, Min Yuan, Xiangqing Ding, Qibin Liao, Jianqing Xu, Cuisong Zhu, Meiqi Feng, Zhuoqun Liu, Lang Jiang, Linxia Zhang
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMJ Publishing Group 2021-10-01
Σειρά:	Journal for ImmunoTherapy of Cancer
Διαθέσιμο Online:	https://jitc.bmj.com/content/9/10/e002755.full
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