Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks

Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimately responsible of amyloid-β (Aβ) formation. Besides its e...

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Bibliographic Details
Published in:Cells
Main Authors: Pizzo, Paola, Basso, Emy, Filadi, Riccardo, Greotti, Elisa, Leparulo, Alessandro, Pendin, Diana, Redolfi, Nelly, Rossini, Michela, Vajente, Nicola, Pozzan, Tullio, Fasolato, Cristina
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601421/
https://ncbi.nlm.nih.gov/pubmed/32992716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102166
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