Identification of Germline Mutations in Melanoma Patients with Early Onset, Double Primary Tumors, or Family Cancer History by NGS Analysis of 217 Genes

Cutaneous melanoma is the deadliest skin malignity with a rising prevalence worldwide. Patients carrying germline mutations in melanoma-susceptibility genes face an increased risk of melanoma and other cancers. To assess the spectrum of germline variants, we analyzed 264 Czech melanoma patients indi...

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Pubblicato in:Biomedicines
Autori principali: Stolarova, Lenka, Jelinkova, Sandra, Storchova, Radka, Machackova, Eva, Zemankova, Petra, Vocka, Michal, Kodet, Ondrej, Kral, Jan, Cerna, Marta, Volkova, Zuzana, Janatova, Marketa, Soukupova, Jana, Stranecky, Viktor, Dundr, Pavel, Foretova, Lenka, Macurek, Libor, Kleiblova, Petra, Kleibl, Zdenek
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601281/
https://ncbi.nlm.nih.gov/pubmed/33050356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8100404
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