Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

Canine and human osteosarcomas (OSA) share similarities. Novel therapies are necessary for these tumours. The Bacillus anthracis toxin was reengineered to target and kill cells with high expressions of matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA). Since canine OSA expre...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Mackowiak da Fonseca, Jonathan, Mackowiak da Fonseca, Ivone Izabel, Nagamine, Marcia Kazumi, Massoco, Cristina de Oliveira, Nishiya, Adriana Tomoko, Ward, Jerrold Michael, Liu, Shihui, Leppla, Stephen Howard, Bugge, Thomas Henrik, Dagli, Maria Lucia Zaidan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601267/
https://ncbi.nlm.nih.gov/pubmed/32987941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins12100614
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