A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Our recent studies have shown that the diamine-(PEG)ylated oleanolic acid (OADP) has strong anti-tumor effects in HCCs. In this study, we evaluated the anti-tumor mechanisms of OADP in the HepG2 HCC cell line. The cytotoxicity r...

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Publicado no:Biomolecules
Main Authors: Jannus, Fatin, Medina-O’Donnell, Marta, Rivas, Francisco, Díaz-Ruiz, Luis, Rufino-Palomares, Eva E., Lupiáñez, José A., Parra, Andrés, Reyes-Zurita, Fernando J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601263/
https://ncbi.nlm.nih.gov/pubmed/32998255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10101375
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