Antiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G(0)/G(1) Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathway

Natural products have a significant role in the development of new drugs, being relevant the pentacyclic triterpenes extracted from Olea europaea L. Anticancer effect of uvaol, a natural triterpene, has been scarcely studied. The aim of this study was to understand the anticancer mechanism of uvaol...

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Bibliographic Details
Published in:Molecules
Main Authors: Bonel-Pérez, Gloria C., Pérez-Jiménez, Amalia, Gris-Cárdenas, Isabel, Parra-Pérez, Alberto M., Lupiáñez, José Antonio, Reyes-Zurita, Fernando J., Siles, Eva, Csuk, René, Peragón, Juan, Rufino-Palomares, Eva E.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571068/
https://ncbi.nlm.nih.gov/pubmed/32947962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25184254
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