Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic brain pathologies. The aim of this study was to...

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Publicado en:Biomolecules
Main Authors: Skemiene, Kristina, Rekuviene, Evelina, Jekabsone, Aiste, Cizas, Paulius, Morkuniene, Ramune, Borutaite, Vilmante
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600544/
https://ncbi.nlm.nih.gov/pubmed/33019635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10101400
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