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Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells

SIMPLE SUMMARY: Dexamethasone (DEX) is commonly used as immunosuppressive and chemotherapeutic agent. The effects of DEX on cell death is different, depending on cell types and stimuli. Here, we found that DEX inhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell dea...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Jeon, Mi-Yeon, Woo, Seon Min, Seo, Seung Un, Kim, Sang Hyun, Nam, Ju-Ock, Kim, Shin, Park, Jong-Wook, Kubatka, Peter, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600459/
https://ncbi.nlm.nih.gov/pubmed/33050333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102901
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