Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression

Polo-like kinase 1 (PLK1) plays major roles in cell cycle control and DNA damage response. Therefore, PLK1 has been investigated as a target for cancer therapy. Volasertib is the second-in class dihydropteridinone derivate that is a specific PLK1 inhibitor. In this study, we examined that combining...

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Main Authors: Mi-Yeon Jeon, Kyoung-jin Min, Seon Min Woo, Seung Un Seo, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2017-11-01
Colecção:International Journal of Molecular Sciences
Assuntos:
volasertib
TRAIL
c-FLIP
caspase
apoptosis
Acesso em linha:https://www.mdpi.com/1422-0067/18/12/2568
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