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Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na(V) Channel Inhibitor
Voltage-gated sodium (Na(V)) channel subtypes, including Na(V)1.7, are promising targets for the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ-conotoxins are small, potent Na(V) channel inhibitors which represent potential drug leads. Of the 22 µ-conotoxins character...
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| Udgivet i: | Biomedicines |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7599555/ https://ncbi.nlm.nih.gov/pubmed/33023152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8100391 |
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