OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes

OBJECTIVES: A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by suppressing the expressions of OA-associated genes. The...

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Vydáno v:Pain Res Manag
Hlavní autoři: Tian, Jian, Cheng, Chao, Kuang, Shi-Da, Su, Chao, Zhao, Xin, Xiong, Yi-lin, Li, Yu-Sheng, Gao, Shu-Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599390/
https://ncbi.nlm.nih.gov/pubmed/33144900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/3428587
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