Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer

The 17q23 amplicon is associated with poor outcome in ER(+) breast cancers, but the causal genes to endocrine resistance in this amplicon are unclear. Here, we interrogate transcriptome data from primary breast tumors and find that among genes in 17q23, PRR11 is a key gene associated with a poor res...

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Publié dans:Nat Commun
Auteurs principaux: Lee, Kyung-min, Guerrero-Zotano, Angel L., Servetto, Alberto, Sudhan, Dhivya R., Lin, Chang-Ching, Formisano, Luigi, Jansen, Valerie M., González-Ericsson, Paula, Sanders, Melinda E., Stricker, Thomas P., Raj, Ganesh, Dean, Kevin M., Fiolka, Reto, Cantley, Lewis C., Hanker, Ariella B., Arteaga, Carlos L.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599336/
https://ncbi.nlm.nih.gov/pubmed/33127913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19291-x
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