YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer

BACKGROUND: N6-methyladenosine (m(6)A) is the most abundant modification in mRNA of humans. Emerging evidence has supported the fact that m(6)A is comprehensively involved in various diseases especially cancers. As a crucial reader, YTHDF2 usually mediates the degradation of m(6)A-modified mRNAs in...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer
Autori principali: Li, Jiangfeng, Xie, Haiyun, Ying, Yufan, Chen, Hong, Yan, Huaqing, He, Liujia, Xu, Mingjie, Xu, Xin, Liang, Zhen, Liu, Ben, Wang, Xiao, Zheng, Xiangyi, Xie, Liping
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599101/
https://ncbi.nlm.nih.gov/pubmed/33121495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01267-6
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