PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unknown. Using proteomic approaches to find PRDM9 partners, we identified HEL...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Imai, Yukiko, Biot, Mathilde, Clément, Julie AJ, Teragaki, Mariko, Urbach, Serge, Robert, Thomas, Baudat, Frédéric, Grey, Corinne, de Massy, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599071/
https://ncbi.nlm.nih.gov/pubmed/33047671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57117
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