Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors

ARID1A, a component of the chromatin-remodeling complex SWI/SNF, is one of the most frequently mutated genes in human cancer. We sought to develop rational combination therapy to potentiate the efficacy of immune checkpoint blockade in ARID1A-deficient tumors. In a proteomic analysis of a data set f...

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Vydáno v:J Clin Invest
Hlavní autoři: Wang, Lulu, Yang, Lin, Wang, Chen, Zhao, Wei, Ju, Zhenlin, Zhang, Wei, Shen, Jianfeng, Peng, Yang, An, Clemens, Luu, Yen T., Song, Shumei, Yap, Timothy A., Ajani, Jaffer A., Mills, Gordon B., Shen, Xuetong, Peng, Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598069/
https://ncbi.nlm.nih.gov/pubmed/33016929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130445
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